Alexander Borst: How do neurons compute the direction of motion?
| When |
Mar 16, 2021
from 05:15 PM to 06:00 PM |
|---|---|
| Where | Zoom Meeting. Meeting ID and password will be sent with the e-mail invitation. You can also contact Fiona Siegfried for meeting ID and password. |
| Contact Name | Fiona Siegfried |
| Contact Phone | 0761 203 9549 |
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Abstract
Detecting the direction of image motion is important for visual navigation, predator avoidance and prey capture, and thus essential for the survival of all animals that have eyes. However, the direction of motion is not explicitly represented at the level of the photoreceptors: it rather needs to be computed by subsequent neural circuits, involving a comparison of the signals from neighboring photoreceptors over time. The exact nature of this process represents a classic example of neural computation and has been a longstanding question in the field. Only recently, much progress has been made in the fruit fly Drosophila by genetically targeting individual neuron types to block, activate or record from them. Our results obtained this way indicate that the local direction of motion is computed in two parallel ON and OFF pathways. Within each pathway, a retinotopic array of four direction-selective T4 (ON) and T5 (OFF) cells represents the four Cartesian components of local motion vectors (leftward, rightward, upward, downward). Since none of the presynaptic neurons turns out to be directionally selective, direction selectivity first emerges within T4 and T5 cells. Our present research focuses on the cellular and biophysical mechanisms by which the direction of image motion is computed in these neurons.
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