Geraldine Zimmer-Bensch: Diverse actions of the DNA methyltransferase 1 in directing cortical interneuron development and function

The spatial and temporal inhibitory actions of the enormously heterogeneously collection of GABAergic interneurons tremendously influence cortical information processing, which is reflected by diseases like autism, epilepsy and schizophrenia that involve defective cortical inhibition. Apart from the regulation of physiological processes like synaptic transmission, proper interneuron function also relies on their correct development. Hence, decrypting regulatory networks that direct subtype-specific cortical interneuron development as well as adult functionality is of great interest, as this helps to identify critical events implicated in the etiology of the aforementioned diseases. Epigenetic mechanisms of gene regulation like DNA methylation executed by DNA methyltransferases (DNMTs) and histone modifications call increasing attention in sculpting physiological processes in the brain relevant for human mental health.

Several studies associate altered expression levels and function of the DNA methyltransferase 1 (DNMT1) in subsets of embryonic and adult cortical interneurons in patients diagnosed with schizophrenia. Although accumulating evidence supports the relevance of epigenetic signatures for instructing cell type-specific development, only very little is known about their functional implications in discrete developmental processes and in subtype-specific maturation of cortical interneurons. Similarly, little is known about the role of DNMT1 in regulating adult interneurons functionality. This talk will provide an overview about newly identified and roles DNMT1 has in orchestrating cortical interneuron development and adult function.

More about the speaker and her research:

Prof. Dr. rer. nat. Geraldine Zimmer-Bensch